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How Cannabinoids Affect REM Sleep: Explained

Author: Edijs Eleksis

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Time: 8 min

Introduction

The link between cannabinoids and sleep is a hot topic in science. It's especially interesting because of how cannabinoids affect REM sleep. This stage is key for dreaming and remembering things.


Cannabis is a plant with over 480 compounds, including about 66 cannabinoids. Delta-9-tetrahydrocannabinol (Δ9-THC) is the main psychoactive part. Cannabidiol (CBD) makes up about 40% of the plant resin extract.


These compounds and the body's endocannabinoid system might change sleep patterns. This could affect health and how well we think. As scientists learn more about cannabis and its effects on the brain, knowing how it impacts REM sleep is getting more important. This is true for both people who use marijuana for fun and those who use it for medical reasons.

Understanding Cannabinoids and Their Classification

To see how cannabinoids affect REM sleep, we need to know what they are and how they're grouped. Cannabinoids are compounds that work with the body's endocannabinoid system. They play a big role in many body functions.

What Are Cannabinoids?

Cannabinoids are compounds that interact with cannabinoid receptors in our bodies. These receptors are part of the endocannabinoid system. This system helps control things like sleep, mood, and hunger. Cannabinoids can come from cannabis, be made by our bodies, or be made in a lab.


People are really interested in cannabinoids because of their possible health benefits, including helping with sleep. Knowing the different types of cannabinoids helps us understand their different effects on our health.

The Three Main Types of Cannabinoids

Cannabinoids are mainly divided into three groups: phytocannabinoids, endocannabinoids, and synthetic cannabinoids. Each group has its own effects on our bodies.


Phytocannabinoids (THC, CBD, CBN) come from plants, with THC, CBD, and CBN being well-studied. THC has psychoactive effects, while CBD might help without making you high. CBN is also non-psychoactive and has been studied for its sleep-inducing properties.


Endocannabinoids are made by our bodies and are key to the endocannabinoid system. They help control many body functions, including sleep and wakefulness.


Synthetic cannabinoids are made in labs to act like natural cannabinoids. They work on the brain's cannabinoid type 1 receptor (CB1R) like THC. But, they can be much stronger and have caused serious problems, including messing with sleep and other health issues.

"Synthetic cannabinoids have been linked to a number of adverse effects, making them a significant public health concern," as noted by health experts.

Woman holding nine realms cannabis flower in her hands
  • Synthetic cannabinoids are made in labs to mimic natural ones but can have unpredictable and more potent effects.
  • They were first made for research but have shown up in the drug market as legal alternatives to marijuana.
  • Unlike natural cannabinoids, synthetic ones can aggressively target CB1 receptors, potentially disrupting normal sleep architecture.
  • Research has shown concerning effects from synthetic cannabinoid use, including sleep problems and psychosis.

The Endocannabinoid System and Sleep Regulation

It's important to understand how the endocannabinoid system affects sleep to see how cannabinoids impact REM sleep. The endocannabinoid system is a complex network that helps keep our sleep-wake cycles in balance. It influences our circadian rhythms and neurotransmitters that help us sleep, ensuring we get a good night's rest.

Cannabinoid Receptors in the Brain

Cannabinoid receptors are key in the endocannabinoid system, especially in the brain. They work with cannabinoids, whether made inside the body or from cannabis or hemp. The brain's area affects how cannabinoids work; for example, they can change memory and how we move.


These receptors are found in important brain areas. They help control how we feel pleasure and pain. This shows how important they are for our health and how we use cannabinoids.

How the Endocannabinoid System Influences Sleep Cycles

The endocannabinoid system changes throughout the day and night. It affects our sleep. Studies show that anandamide levels go up when we're tired, helping us sleep.


This system works with other sleep helpers like GABA and serotonin. Adding cannabinoid products, like vapes or gummies, can change how we sleep and dream.

REM Sleep: Function and Importance

REM sleep is vital for our health. It helps us in many ways. It's a special stage of sleep with unique brain activity.

The Stages of Sleep

Sleep has different stages, including REM and non-REM. Non-REM sleep has three parts with different brain waves. REM sleep has fast eye movements and brain activity like being awake.


Each sleep cycle lasts about 90 minutes. People usually have several cycles a night. The amount of REM sleep changes as we get older.

The Unique Characteristics of REM Sleep

REM sleep is special. Brain activity is like being awake. It's important for processing emotions and memories.


This stage helps us deal with emotions and learn new things. It's also when we dream. Research shows that problems with REM sleep can affect our thinking and feelings.

Cannabinoids and Their Impact on REM Sleep

It's important to know how cannabinoids affect REM sleep. They can have good and bad effects. Cannabinoids interact with our endocannabinoid system, which helps control sleep.

THC's Effects on REM Sleep Duration and Quality

THC, the active part of cannabis, changes how we sleep. Studies show it can cut down on REM sleep. This might affect how well we remember things and handle our emotions.


A study found THC users slept less REM sleep than non-users. This shows THC can change our sleep patterns. It might make our sleep quality worse.


Aspect of REM Sleep

Effect of THC

Duration

Reduced

Quality

Altered

Cognitive Function

Potential Impact

CBD's Influence on Sleep Architecture

CBD, a part of cannabis that doesn't get you high, affects sleep differently. It might not cut down REM sleep as much. CBD could help our sleep patterns stay normal.


But CBD's effects on sleep are complex. Low doses might make us more alert, while high doses can make us sleepy. More research is needed to understand how CBD can help with sleep problems.


  • CBD might help with REM sleep behavior disorder, especially in people with Parkinson's disease.
  • Its ability to support sleep without messing with natural sleep patterns makes it interesting for sleep research.
Nine realms customer sleeping in the bedroom under a blanket

The Science Behind Cannabinoid-Induced Sleep Changes

Research shows how cannabinoids, like THC and CBD, change our sleep. They work with our body's endocannabinoid system to affect our sleep patterns.

Receptor Activation and Sleep Modulation

Cannabinoids, like THC, work on our brain's CB1 receptors to change sleep. They can make GABA, a relaxant, release more in some parts of the brain. This helps us relax and sleep better.


They also stop acetylcholine, a brain chemical, from making us dream. This can cut down on REM sleep, which is common with cannabis use.

Neurochemical Changes During Cannabinoid Use

Using cannabinoids changes our brain chemistry, affecting sleep. They can change adenosine levels, which help us fall asleep. They also affect other chemicals and hormones that control sleep.


Neurotransmitter/Hormone

Effect of Cannabinoids

Impact on Sleep

Adenosine

Alters levels

Promotes sleep initiation

GABA

Enhances release

Increases slow-wave sleep

Acetylcholine

Suppresses release

Reduces REM sleep

Melatonin

May alter production or signaling

Affects sleep timing and quality

Long-term use of cannabinoids can change how our brain controls sleep. This might explain why we get used to their effects and why stopping use can disrupt sleep.

Summary: Cannabinoids affect brain chemicals like adenosine, GABA, and melatonin, which can help you fall asleep but also change sleep quality. Over time, your brain may adapt to these changes, making sleep harder without them.

Therapeutic Applications of Cannabinoids for Sleep Disorders

Cannabinoids are being studied for treating sleep disorders. They might help improve sleep-wake cycles. This could lead to new treatments.

Cannabinoids for Insomnia Treatment

Cannabinoids might help with insomnia, a common sleep problem. Studies show they can improve sleep quality. Medical cannabis could be a good option for those who don't respond to other treatments.

Potential Benefits for PTSD-Related Sleep Disturbances

People with PTSD often have trouble sleeping. Up to 90% of them have sleep issues. THC might help by reducing nightmares.


Cannabidiol (CBD) could also help with PTSD nightmares. Nabilone, a synthetic cannabinoid, has helped veterans with PTSD. The endocannabinoid system might help process traumatic memories.

Potential Risks and Side Effects of Using Cannabinoids for Sleep

Cannabinoids might help with sleep, but they also have risks. It's important to know the downsides of using them for sleep.

Short-Term Effects on Sleep Quality

Cannabinoids can affect sleep differently for everyone. Chronic use might make you need more to sleep well. This can create a cycle that worsens sleep problems.


  • Some people find cannabinoids help them relax and sleep better.
  • But, regular use can make you rely on them for sleep, disrupting natural patterns.

Long-Term Implications for Sleep Architecture

Long-term, heavy use of cannabis can change sleep patterns. Studies show it can reduce slow-wave sleep and alter REM patterns. This could affect memory and creativity.


Young people might be more at risk for these changes. Their brains are still developing, and sleep is important for growth. It's key for them to consider these risks when thinking about using cannabinoids for sleep.

Conclusion

Cannabinoids' effects on REM sleep show the balance between benefits and risks. The impact on REM sleep varies by person. It depends on the type of cannabinoid, dosage, and individual physiology.


For some, like those with PTSD or chronic pain, cannabinoids might be worth the risks. But for others, especially healthy individuals, the risks might outweigh the benefits. This is especially true for long-term use.


More research is needed to find safer, more effective cannabinoids for sleep. People considering cannabinoids should talk to a doctor. They should also watch how it affects their sleep and daily life.


By being careful and informed about using cannabis products, people can make smart choices. This might help them sleep better and feel healthier overall.

“The biggest killer on the planet is stress, and I still think the best medicine is and always has been cannabis.”

Willie Nelson

FAQs about How Cannabinoids Affect REM Sleep

What are the primary cannabinoids found in the cannabis plant?

The cannabis plant has many cannabinoids, with THC and CBD being the most famous. THC makes you feel high, while CBD doesn't. CBN and CBG are also important cannabinoids.

How do cannabinoids interact with the body?

Cannabinoids work with the body's endocannabinoid system. This system helps control things like sleep, pain, and mood. It has CB1 and CB2 receptors that cannabinoids activate.

Can cannabinoids be used to treat sleep disorders?

Studies show that THC and CBD might help with sleep problems. This includes insomnia and sleep issues linked to PTSD.

Pretty Cool Nine Realms Blog Author

Author: Edijs Eleksis

Growing up in a country where cannabis was stigmatized and even shamed, Edijs faced many roadblocks to get to enjoy the benefits of this plant. However, as more countries worldwide are opening up to the idea of cannabis-available society, Edijs is inspired to take on a mission: spreading awareness about cannabis and its industry in Europe through engaging, educational blog content. Because only with more information, humans as a collective, can make decisions that are better for all of us!

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