Cannabis flower and oil

THC vs. CBD: Guide

Author: Jans Beloglazovs

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Time: 8 min

People are increasingly interested in the potential benefits of cannabis, with the buzz often centering on CBD vs. THC. They're both found in cannabis plants but you might be wondering about the THC and CBD difference and how they impact your experience. We’re going to dive into the specifics so you understand those distinctions.


Understanding the differences of CBD vs THC will let you choose a product that works for you. So whether you’re new to these cannabis plant compounds (cannabinoids) or you want more clarity on what sets them apart, let’s break it down. 

TL;DR:
Cannabis has a lot of cannabinoids, but THC and CBD are the most important ones. They have very different effects on your body. When THC binds to CB1 receptors in the brain, it makes you feel high. CBD, on the other hand, works best with CB2 receptors and doesn't get you high. It helps keep things in check. THC works faster and better, but it also has more risks, especially with very strong products. CBD is safe to use and is often used for health, but the quality of the products can vary, so it's a good idea to have someone else test them. It depends on what you want to get out of it, how much you can handle, and what kind of experience you want: calm or euphoria, clarity or intensity.

The chemical structure of CBD and THC

THC Chemical structure made from Nine Realms lab
THC structure
CBD chemical structure made in the Nine Realms lab
CBD structure

Both THC (tetrahydrocannabinol) and CBD (cannabidiol) exist as naturally occurring compounds within the cannabis plant, commonly known as marijuana. This incredible plant contains more than 100 different cannabinoids, including some of the most popular:


that exert specific effects by interacting with our bodies' intricate endocannabinoid system (ECS). The ECS plays a critical role in regulating various physiological processes, including mood, sleep, appetite, pain perception, and immune response.

THC: The Intoxicating Cannabinoid

THC is the main psychoactive compound in cannabis that produces the "high" sensation. It primarily binds to the CB1 receptors, concentrated in the brain and central nervous system. This interaction causes the psychoactive effects that cannabis is known for.


While often associated with recreational cannabis, THC has shown potential therapeutic applications for various ailments, such as:


  • chronic pain
  • nausea
  • appetite loss

Some people even use THC to help stimulate appetite.

Man and Woman smoking nine realms THC joint

CBD: The Non-Intoxicating Counterpart

CBD, on the other hand, acts differently within the ECS. Instead of directly binding to the CB1 receptors, CBD works more indirectly, modulating their activity. This key difference is why CBD doesn’t cause the same intoxicating effects as THC, making it an increasingly popular choice for those seeking potential therapeutic benefits without the high.


CBD products come in various forms, such as:


  • CBD gummies
  • CBD oil
  • CBD Vapes

While pure CBD is generally considered safe, it is important to note that some CBD products, especially nonprescription CBD products, may contain higher levels of THC than advertised.

Woman working out after smoking Nine Realms CBD joints

The Main Differences: THC vs. CBD


Feature

THC

CBD

Psychoactive effects

Produces a "high."

Non-psychoactive.

Legal Status (EU)

THC is generally illegal for recreational use, some countries have made strides towards legalizing medical cannabis.

CBD is generally considered legal in the EU as long as it's derived from hemp plants with a THC content below the legal limit (usually 0.3%)

Potential Therapeutic Uses

Pain relief, nausea and vomiting relief, appetite stimulation, muscle spasm control.

Pain management, anxiety and depression relief, epilepsy and seizure control, inflammation reduction.

Side Effects

Can cause anxiety, paranoia, dry mouth, red eyes, increased heart rate, impaired memory and coordination (short-term).

Generally well-tolerated with potential side effects like fatigue, diarrhea, changes in appetite, and possible interactions with other medications.

THC vs. CBD: Navigating The Legal Jungle

The legality surrounding THC vs CBD is complex and ever-changing. While the information above provides a general overview, always do your research and stay informed on your specific regional laws regarding cannabis and its derivatives. The EMA has approved certain prescription drugs containing THC or CBD for specific conditions. However, it's crucial to remember that THC and CBD are still considered controlled substances under European law.


For instance, while hemp-derived CBD with less than 0.3% THC is legal hemp and legal on a European level, it's essential to know the specific regulations of the country you are in, as individual country laws may still prohibit its sale or possession. This can make things especially tricky if you're traveling across state lines. Be sure to check out information from resources like the EMCDDA for updated information. 

Decoding CBD vs THC Effects on Your Body and Mind

Understanding the potential impacts and differences between CBD and THC on your physical and mental functions will guide how you choose your cannabis products. While there is quite a bit of information around these responses, researchers are still digging deeper. They’re conducting ongoing studies to unveil the mysteries of THC and CBD difference as more information comes out.

THC has a big effect on the body and mind because it attaches to CB1 receptors in the brain. THC can do a lot of things, like:


  • Change the way you see, hear, and think about things to make them seem more real.

  • Get more dopamine to work so you feel better.

  • Change how well you work together and how quickly you respond.

  • Make you hungry and more aware of what you see, hear, and feel.

  • It can make them feel relaxed or happy, depending on how much they take and how tolerant they are.

You should be careful with THC because of these effects, especially in products that have a lot of it.

CBD, on the other hand, works in a different way. It doesn't make you feel high because it doesn't connect to CB1 receptors in the same way. But CBD:


  • It has an indirect effect on both CB1 and CB2 receptors, which helps keep things in check.

  • It changes how serotonin and cortisol move through the body so that it can handle stress better.

  • Changes the body's signals for swelling.

  • Keeps you calm and focused without making things harder to figure out.

  • When both are present, the effects of THC are less strong.

Because it has mild and steady effects, many people use CBD during the day and as part of their long-term health routine.

In other words, you can say that THC and CBD have different but good effects on your body. THC gives you energy, and CBD helps you feel calm. They make the experience bigger and better when used together. But the right choice depends on what you want, how you feel, and how you use them.

Conclusion

THC and CBD have very different effects on how cannabis makes you feel. Knowing these differences can help you make a better choice. THC has strong effects on the mind because it binds directly to CB1 receptors in the brain. CBD, on the other hand, works with CB2 receptors. This keeps your body in balance without making you feel high. Cannabinoids affect sleep, pain, mood, and overall health, but they do so in different ways.


You need to pick between calm and euphoria, or clarity and intensity, depending on what you want. THC gives you a strong high, but it also has more risks, especially with very strong products. CBD is good for you, but you should only buy products that have been tested in a lab to be sure you know what you're getting. When you know how each cannabinoid affects your body, you can have a better experience with every product you use and make better choices.

"It is in the nature of humans to prefer one thing to another, to find one thing more meaningful than another."

Susanna Clarke

FAQ

What is the difference between CBD and THC?

The difference is that THC produces psychoactive effects, while CBD does not. This is because they interact differently with our body's endocannabinoid system. THC binds with CB receptors in a way that produces a "high," while CBD does not.

Is CBD more effective than THC?

It depends on the result that you want to achieve. THC provides a euphoric feeling, while CBD is more known for feelings of relaxation without the "high." CBD binds to cannabinoid receptors differently than THC, leading to differing effects.

What are the benefits of THC for the body?

THC interacts with the body's endocannabinoid system (ECS) primarily by binding with the CB1 receptors, which in turn helps regulate things such as sleep, appetite, pain, and mood. Both THC and CBD have been studied for their potential therapeutic benefits, and clinical studies suggest that THC can be helpful in treating nausea, particularly vomiting caused by chemotherapy. Some people use medical marijuana to provide relief from various conditions.

Does CBD make you feel high?

CBD is not known for making you feel "high" because it is non-psychoactive and does not cause the same "high" as THC. You may experience relaxation or reduced anxiety. CBD is often favored by those seeking the potential medical benefits of cannabis without the intoxicating effects. Additionally CBD can be used to counter THC side effects such as paranoia and anxiety.

What makes you stoned, THC or CBD?

THC is the cannabinoid that gets you high. It sticks to CB1 receptors in the brain very well, which changes how you think, feel, and move. CBD doesn't bind to CB1 receptors in the same way, so it doesn't make you feel high. When they are in the same product, CBD can even make THC less strong.

Will you test positive for THC if you smoke CBD?

What you want to buy will determine. It doesn't usually show up on drug tests because pure CBD has very little THC in it. But a lot of CBD products, especially full-spectrum blends, do have some THC in them. If you use them a lot, they can build up enough THC in your body to show up on a drug test. If you want to stay away from THC completely, look for products that are broad-spectrum or THC-free and read lab reports from other companies.

What are the benefits of CBD without THC?

Without THC, CBD gives you a clear, non-drugged experience. This is a good choice for people who want to feel balanced but don't want to get high. CBD changes CB2 receptors, which control mood, how the body handles stress, inflammation, and overall balance. Many people use CBD to relax, focus, and heal, especially during the day when THC would be too strong. The most important thing is how good the goods are. Clean formulas and tests that have been checked give the best and safest results.

A man smoking Nine Realms vape

Author: Jans Beloglazovs

Emerging from Europe's strict cannabis landscape, Jan has become a known figure in the European cannabis industry through vast experience in cannabusiness and a keen understanding of the shifting trends in Europe. Co-founding the Nine Realms cannabis brand, he leverages his expertise to advocate for progressive cannabis policies and educate a broad audience.

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