Cannabinoids For Skin Conditions: Explained

Cannabinoids are chemical compounds in the cannabis sativa plant. Two of the most well-known cannabinoids include tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is psychoactive, while CBD is primarily known for its therapeutic potential, and doesn't cause a high.

Cannabinoids interact with the body's endocannabinoid system (ECS). This system influences several bodily functions, including skin health, as human keratinocytes have cannabinoid receptors. When cannabinoids bind to these receptors, they may influence inflammation, pain, and cell growth, and could be an effective treatment.

Many consider cannabinoids a potential treatment for various skin diseases. Preclinical research suggests several potential benefits of cannabis sativa.

Acne, a common skin issue, is often caused by excess oil production, clogged pores, and inflammation. CBD products might reduce sebum production from sebaceous glands. Topical cannabinoids’ anti-inflammatory properties may also improve acne.

Cannabinoids might offer relief for those with eczema or dry, itchy skin. The anti-inflammatory effects may reduce flare-ups, easing these uncomfortable symptoms. Research explored cannabinoids' effects on reducing dryness and itchiness.

Psoriasis is a chronic autoimmune skin disease. Initial research indicates potential benefits of using topical cannabinoid for skin conditions like psoriasis, affecting epidermal keratinocyte proliferation.

Some studies have indicated that topical and oral cannabinoids can promote wound healing by reducing inflammation and promoting tissue repair.

Topical CBD and other non-psychoactive cannabinoids may be helpful in managing the itching, inflammation and overall severity of atopic dermatitis (eczema). The research so far has produced mixed results and therefore further research is needed to solidify their effectiveness in managing the inflammatory skin disease.

The current evidence suggests that cannabinoids have the therapeutic potential to address pain management and reduce inflammation associated with the rare, blistering skin condition, epidermolysis bullosa.

Although studies examining topical or oral cannabinoids as an effective treatment for lichen simplex chronicus (LSC) are lacking, some anecdotal reports indicate that topical cannabinoids might be a safe option for alleviating localized itching caused by LSC, as well as improving the anxiety and depression sometimes associated with it.

Preclinical studies on topical and systemic cannabinoids for skin conditions such as systemic sclerosis (SSc) suggest that these compounds may offer therapeutic effects in the treatment of the inflammatory skin disease by their ability to modify the activity of TRP channels (transient receptor potential channels), thus influencing cellular responses, and providing potential therapeutic effects. The current research is promising, although further clinical trials are necessary to determine the efficacy of topical cannabinoids for treating this inflammatory skin condition.

Research on cannabinoids' influence on skin cancer shows mixed results. Some studies show a potential connection; however, there’s no definitive evidence yet for efficacy against human skin cancers. Topical and oral cannabinoids for skin conditions such as cancer warrant further investigation, especially considering some in-vitro evidence on multiple cancer cell lines.

Various cannabinoids can be consumed differently. Cannabidiol (CBD) oil, tinctures, or lotions are common forms applied directly to the skin. You may even use a high potency hash oil topical.

Finding the right dose is essential. Start with a low dose and gradually increase, especially for new users. Always talk to your dermatologist or doctor for professional guidance on the potential adverse effects of CBD products or Tetrahydrocannabinol (THC) on your particular inflammatory skin condition, before using it as an effective treatment.

While generally safe, cannabinoids can cause side effects. These adverse effects might include:

• Dry mouth
• Appetite changes
• Drowsiness

Topical cannabinoid use has also been rarely associated with allergic contact dermatitis, usually linked to other components of the preparation, rather than the cannabinoids themselves.

There's also the possibility of drug interactions. Consult a dermatologist to evaluate any potential interactions or adverse effects, especially for conditions affecting the adnexal structures.

Current research on cannabinoids for skin conditions like seborrheic dermatitis is growing, but much of it is still preliminary. Some preclinical evidence supports the use of medical cannabis as an effective treatment.

The National Academies of Sciences, Engineering, and Medicine reviewed research on the health effects of cannabis and cannabinoids, but they found limited high-quality research, specifically regarding dermatologic applications.

It's important to approach any benefit claims with skepticism. Do your research, and always consult a doctor before using cannabinoids for skin issues.